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How `chameleon-like` breast cancer cells lead to brain tumors

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    Published on 20 January 2014
    Author
    247 News Around The World

    Getting rid of breast cancer cells does not ensure that the disease won’t spread to the brain. A study by City of Hope researchers have explained why? They have found that breast cancer cells disguise themselves as neurons, allowing them to hide from the immune system, cross the blood-brain barrier and begin to form ultimately-deadly brain tumors years after initial diagnosis. Rahul Jandial, a City of Hope neurosurgeon who led the study, wanted to explore how breast cancer cells cross the blood-brain barrier, a separation of the blood circulating in the body from fluid in the brain, without being destroyed by the immune system. Also Read – Brain tumour: 5 existing treatment options you must know about

    Jandial said that his team wondered how a malignant breast cancer cell swimming in the bloodstream crossed into the brain and how it would survive in a completely new, foreign habitat. Jandial and his team’s hypothesis: Given that the brain is rich in many brain-specific types of chemicals and proteins, perhaps breast cancer cells exploit these resources by assuming similar properties.
    Also Read – Risk factors of brain tumour you should know about

    These cancer cells could potentially deceive the immune system by blending in with the neurons, neurotransmitters, other types of proteins, cells and chemicals. Taking samples from brain tumors resulting from breast cancer, Jandial and his team found that the breast cancer cells were using the brain’s most abundant chemical as a fuel source.
    Also Read – Dim light escalates breast cancer’s spread to bones: Study

    See also  James Argent is seen for the first time since 'surgery to remove his excess skin'

    This chemical, GABA, is a neurotransmitter used for communication between neurons. When compared to cells from non-metastatic breast cancer, the metastasized cells expressed a receptor for GABA, as well as for a protein that draws the transmitter into cells.

    This allowed the cancer cells to essentially masquerade as neurons. Jandial added that breast cancer cells can be cellular chameleons (or masquerade as neurons) and spread to the brain. The study will be published in the Proceedings of the National Academy of Sciences.

    Source: ANI

    For more articles, visit our Diseases and Conditions Section and for videos check out our YouTube Channel. Don’t miss out on the latest updates. Follow us on Facebook, Twitter and Google Plus.

    Published : January 20, 2014 12:56 pm | Updated:June 7, 2021 10:47 am

    Source: | This article originally belongs to thehealthsite.com

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